SURGICAL TREATMENT OF MAJOR DEPRESSION
Depression is a prevalent and often debilitating psychiatric disorder with a 6-month prevalence of approximately 5%. In the United States alone, approximately 20 million people have been diagnosed with depression at some point in their lives. Depression accounts for the greatest number of missed work days due to illness, with an estimated economic burden of approximately $40 billion per year. When diagnosing depression, a distinction must be made between major depressive disorder (MDD) and major depressive episode (MDE). For the diagnosis of MDE, patients must present at least five of the following symptoms for a minimum of 2 weeks: depressed mood; markedly diminished interest or pleasure or significant apathy; significant change in appetite or weight; insomnia or hypersomnia; psychomotor agitation or retardation; fatigue or loss of energy; feelings of worthlessness, excessive or inappropriate guilt, or loss of self-esteem; indecisiveness or diminished ability to think or concentrate;